|
KMID : 0811720100140050249
|
|
Korean Journal of Physiology & Pharmacology
2010 Volume.14 No. 5 p.249 ~ p.256
|
|
|
Gender-Related Differences in a Process of the Age-Dependent Alterations of the Elements in Monkey Sino-Atrial Node
|
|
Satoh Hiroyasu
Tohno Setsuko
Minami Takeshi
Oishi Takao
Hayashi Motoharu
Tohno Yoshiyuki
|
|
|
Abstract
|
|
|
|
Gender differences in the trace elements of monkey sino-atrial (SA) node were investigated in a process of age-dependent alterations. Sixty hearts from Japanese and rhesus monkeys (30 male and 30 female) used were aged ranging from 1-day- to 30-year-old. The elements were analyzed using an inductively coupled plasma-atomic emission spectrometer (ICP-AES). Advancing age decreased all the trace elements. Ca, P, S and Mg significantly decreased. The correlation coefficients of Ca and P were ?0.178±0.081 (p＜0.05) and ?0.088±0.022 (p＜0.05) in male (n=30), and ?0.095±0.026 (p＜0.05) and ?0.069±0.017 (p＜0.05) in female (n=30), respectively. The age-dependent coefficients for Fe/Ca, Zn/Ca, Fe/P, Fe/S, Zn/S, Fe/Mg and Zn/Mg were exhibited markedly in male, but all was less in female. In gender-related differences, only a ratio of P/Ca (p＜0.05) was significantly observed with ageing. The trace elements such as Cu, Se and Sn were less detected in the SA nodes. These results indicate that the age-dependent changes in the ratios of elements are appeared more rapidly in male monkey SA node, and the gender difference is observed in ratio of P/Ca. The different attenuations may be involved with the age- and gender-related SA nodal functions.
|
|
|
KEYWORD
|
|
|
Gender difference, Trace elements, Age-dependent alteration, Cardiac pacemaker, Monkey sino-atrial node
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|